The Marseille venue will be new to the Heineken Cup, but not to Toulon. They have played a number of Top 14 games 65km 'up the road' and were beaten there by Cardiff Blues in the 2010 Amlin Challenge Cup final.
Munster may have lost their last three semi-finals, but they know all about what it takes to make the final step.
This will be their record 11th semi-final, and an eighth for talisman Paul O'Connell. The Ireland and British & Irish Lions lock legend will be critical to his side's chances of success with his command of the line-out vital against a Toulon side still uncertain over the fitness of Ali Williams and Bakkies Botha.
With club captain Paul O'Mahony ruled out for the rest of the season with a shoulder injury, two-time Heineken Cup winner O'Connell will lead the red army into battle on French soil. They almost over-turned ASM Clermont Auvergne at the same stage last year and have beaten Toulouse and Castres Olympique at this stage in France in the past.
Toulon only lost one game en route to the knock-out stages, topping Pool 2 with 24 points to advance as third seeds. Their only defeat came away at Cardiff Blues when they slipped to a shock 19-15 defeat.
They had to battle past three-time champions Leinster Rugby at their Stade Felix Mayol home in the last round, comfortably defeating the Amlin Challenge Cup and PRO12 champions 29-14.
Johnny Wilkinson went off with a hamstring injury in that match and hasn't played since, but both he and fellow Rugby World Cup winner Bryan Habana, who has been suffering from a thigh injury, have both been passed fit to play this weekend.
Munster lost their opening game against Edinburgh Rugby at Murrayfield, but have since gone on to win six games in a row. They clinched the final home tie in the quarter-finals and thumped heavyweights Toulouse as they ran in six tries in an outstanding 47-23 victory at Thomond Park.
Toulon warmed-up for their semi-final with a 46-31 victory over Perpignan in Barcelona last weekend and have lost only three times in 13 outings to date this year. Munster were beaten at home by Glasgow Warriors two weeks ago and have lost two of their last five matches.
- This will be Munster's 11th Heineken Cup semi-final, and they now hold the record for most semi-final appearances by-passing Toulouse who had also reached the last four on 10 occasions prior to this season.
- Toulon have won all 12 of their Heineken Cup games when they have either been at home, or have had home country advantage.
- The two clubs met in the pool stage of the 2010/11 tournament with both registering impressive home wins.
- Reigning champions Toulon are appearing in a second Heineken Cup semi-final; last season they dispatched Saracens at this stage.
- Munster have won four semi-finals, and have gone on to win the final on two occasions in 2006 and 2008.
- Munster have the best penalties conceded record in the Heineken Cup this season, giving away an average of just 8.3 penalties/free-kicks per game.
- The Irish province have also been the most effective side at the breakdown, winning more turnovers per game (12.1) and achieving the best ruck success rate (97%).
- Toulon have averaged more penalty kicks at goal per game (3.9) than any other clubs in the Heineken Cup this season with tournament joint-top points scorer Jonny Wilkinson knocking over a competition high 19.
- Wilkinson and Munster's Ian Keatley are level at the top of the points scoring charts for this season with 79 apiece.
- Steffon Armitage is top of the turnovers-won chart in the Heineken Cup this season with 17.